Types of PI

Primary Immunodeficiency (PI) is an umbrella term for over 300 genetic defects and disorders of the immune system recognized by the World Health Organization. Together they affect approximately 29,000 Canadians. Primary Immunodeficiency is not considered a rare disease as a category, but each individual form of PI is rare.

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There are 1 names in this directory beginning with the letter L.
Leukocyte Adhesion Deficiency
Individuals with LAD type 1 are susceptible to severe bacterial and fungal infections from birth. Symptoms of LAD type 1 are bacterial and fungal infections affecting the skin and mucous membranes; severe gingivitis and periodontitis leading to tooth loss; and wounds that are slow to heal. Leukocyte Adhesion Deficiency type 1 is a serious condition that can be life-limiting. LAD1 is by far the most common cause of leukocyte adhesion deficiency and it is usually corrected by bone marrow transplantation. There are milder forms of LAD1 that can be treated with antibiotics alone. LAD type 2 occurs with mutations in an enzyme that attaches fucose (a type of sugar) to proteins. LAD 2 can be treated by eating large quantities of fucose. LAD type 3 is caused by mutations in a gene called FERMT3. Credits: Immune Deficiency Foundation, Genetics Home Reference
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